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Introducing GPT-5.2

AI for Nonprofits: Prompting 101

Kyle Behrend

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A replay of our January 28th webinar, ChatGPT at Work: What top performers are doing differently with ChatGPT.
# Foundational AI Literacy
In Miles City, Montana (pop. 8,400), family physician Dr. Marjorie Albers practices the kind of wide-scope medicine rural America still depends on, and she uses AI tools to make her workload sustainable.
# healthcare
# medicine
With ChatGPT, Ayrin Santoso found a way to navigate care for her mother, Fifi, who lives in the Indonesian city of Surabaya. Ayrin, a tax professional working for OpenAI in San Francisco, had already been using ChatGPT regularly, driven by a duty she feels to her aging parents: “How can I actually still be there and help them when they need something?”
# Use Cases
# medicine
# healthcare
# Indonesia
An overview of common admin responsibilities and resources.
# Administrators
# Launch
# Workspace setup
After a life-threatening rare autoimmune clotting disorder left Rich Kaplan facing kidney damage, his prescribed medication stalled for months because an insurer demanded evidence the drug worked for a condition as uncommon as catastrophic antiphospholipid syndrome. Kaplan used ChatGPT to assemble a referenced synthesis of trials, case reports, and studies, paired with a plain-language note explaining what was at stake; the packet ultimately helped secure approval through third-party arbitration. Since then, he has used ChatGPT as a practical tool for navigating the ongoing complexity of chronic illness, checking potential drug interactions against his medication list, flagging risks tied to kidney disease, and translating dense medical records into clear summaries and questions for clinicians. For Kaplan, the value is agency: turning scattered information and bureaucratic friction into actionable support that helps him pursue better care and stay actively involved in his own health decisions.
# healthcare
Casey Cuny, a 10th-grade Honors English and Senior Mythology teacher at Valencia High School and California’s 2024 Teacher of the Year, uses ChatGPT to convert students’ interests into stronger writing and deeper inquiry. His “Elaboration Conversation” prompt turns ChatGPT into a coach that offers a claim and evidence on any student-chosen topic, then pushes students to defend the idea using reasoning and rhetorical techniques taught in class. Run as a twice-weekly warmup, the activity coincided with students scoring 23% higher than the school average on a district writing assessment, while shifting classroom energy toward engaged, self-driven work. Cuny’s framework keeps the relationship-centered core of teaching intact: students draft, ChatGPT supports practice and structured questioning, and the teacher provides the human feedback and final guidance.
# education
Junevity is a new biotech co-founded by entrepreneur Rob Cahill, UCSF scientists Janine Sengstack and Hao Li, and veteran CEO John Hoekman, with a mission to reprogram aging cells using small interfering RNA (siRNA). Cahill’s path from software founder to bioinformatics and lab work was shaped by family experiences with aging and Parkinson’s, pushing him toward preventive, disease-modifying therapies. From day one, Junevity made AI part of its operating system: every employee gets ChatGPT, and OpenAI models augment the company’s genomics and machine-learning pipelines. The team estimates its first development candidate, a liver-targeted siRNA program for Type 2 diabetes and obesity, can reach key milestones at 2–6x lower cost and 2–3x faster timelines than typical industry norms.
# startup
# biotech
Probably Genetic funds free at-home genetic testing and counseling, pairing it with an AI-driven symptom intake that converts long, free-form narratives into structured phenotype data and candidate diagnoses. For Elizabeth “Betsy” Minium and her daughter Kali, that approach ended a 31-year search marked by inconclusive labels and dead ends, culminating in a Pitt-Hopkins syndrome diagnosis tied to loss of function in one copy of the TCF4 gene.
# healthcare
# science
# medicine
Immunologist Dr. Oral Alpan is using GPT-5 Pro to surface new uses for existing FDA-approved drugs by starting from real-world clinical vignettes and working backward to mechanism. A patient with severe eczema and Food Protein Induced Enterocolitis Syndrome (FPIES) stopped reacting to wheat after beginning dupilumab, then relapsed when coverage lapsed and improved again after restarting, prompting Amerimmune to document additional cases. To test whether AI could connect the dots before the observation became part of the literature, Alpan’s team provided GPT-5 Pro the de-identified case and received dupilumab as the top-ranked candidate, alongside mechanistic rationale and risk considerations. The same workflow is now being applied to other conditions where immune subtypes may be hiding in plain sight, helping prioritize repurposing candidates such as fevipiprant for prospective study in areas like IBS and POTS.
# healthcare
# medicine
# research
# science
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