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Introducing GPT-5.2

AI for Nonprofits: Prompting 101

Kyle Behrend

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Junevity is a new biotech co-founded by entrepreneur Rob Cahill, UCSF scientists Janine Sengstack and Hao Li, and veteran CEO John Hoekman, with a mission to reprogram aging cells using small interfering RNA (siRNA). Cahill’s path from software founder to bioinformatics and lab work was shaped by family experiences with aging and Parkinson’s, pushing him toward preventive, disease-modifying therapies. From day one, Junevity made AI part of its operating system: every employee gets ChatGPT, and OpenAI models augment the company’s genomics and machine-learning pipelines. The team estimates its first development candidate, a liver-targeted siRNA program for Type 2 diabetes and obesity, can reach key milestones at 2–6x lower cost and 2–3x faster timelines than typical industry norms.
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# biotech
Probably Genetic funds free at-home genetic testing and counseling, pairing it with an AI-driven symptom intake that converts long, free-form narratives into structured phenotype data and candidate diagnoses. For Elizabeth “Betsy” Minium and her daughter Kali, that approach ended a 31-year search marked by inconclusive labels and dead ends, culminating in a Pitt-Hopkins syndrome diagnosis tied to loss of function in one copy of the TCF4 gene.
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Immunologist Dr. Oral Alpan is using GPT-5 Pro to surface new uses for existing FDA-approved drugs by starting from real-world clinical vignettes and working backward to mechanism. A patient with severe eczema and Food Protein Induced Enterocolitis Syndrome (FPIES) stopped reacting to wheat after beginning dupilumab, then relapsed when coverage lapsed and improved again after restarting, prompting Amerimmune to document additional cases. To test whether AI could connect the dots before the observation became part of the literature, Alpan’s team provided GPT-5 Pro the de-identified case and received dupilumab as the top-ranked candidate, alongside mechanistic rationale and risk considerations. The same workflow is now being applied to other conditions where immune subtypes may be hiding in plain sight, helping prioritize repurposing candidates such as fevipiprant for prospective study in areas like IBS and POTS.
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Clinical Mind AI is a Stanford-origin platform and research program led by Marcos Rojas Pino that trains clinical reasoning through realistic, decision-based simulations delivered by text and real-time voice. Built on OpenAI’s API and developed from an early laptop prototype into a full platform, it lets instructors author cases and gives learners a telehealth-style interface with an electronic health record for documenting histories, reviewing images, and ordering tests. The system targets two core gaps that separate novices from experts: asking effective questions to gather data and recognizing which findings matter for diagnosis, treatment, referral, and disposition decisions.
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# Higher Education
At Scripps Research, PhD candidate Marco Uytiepo studies how neural circuits store experience by analyzing immense electron-microscopy datasets and reconstructing brain wiring across millions of synapses. Trained primarily as an experimental scientist, he taught himself to code and now uses ChatGPT to accelerate the unglamorous work that makes modern neuroscience possible: building data pipelines, debugging scripts, and automating 3D reconstruction workflows across tools like MATLAB, Python, and Blender. Work that previously required days of iteration can be reduced to rapid cycles that produce usable code and clearer visualizations, supporting faster hypothesis testing and more experiments within a single project.
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Dr. Fleurique Franke, a general practitioner in the Netherlands, uses custom GPTs to streamline routine work in her clinics while improving the quality and tone of patient communication. By drafting clear, guideline-based responses to hundreds of e-consult messages and tailoring explanations to different reading levels, ChatGPT helps her team respond faster without losing empathy or precision. The time saved, roughly a third of her daily message workload, is reinvested in care, training, and follow-up, showing how AI can modernize clinical workflows while keeping medicine humane and accessible.
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Navy veteran and educator Stephen K. Hudson founded AI Ready Veteran to give service members and their families scalable, just-in-time career coaching during the high-friction transition to civilian work. Drawing on two decades as a Navy data analyst, he built a suite of custom GPT tools that translate military roles into civilian competencies, generate tailored resumes, simulate multi-round interviews with voice practice, and coach newcomers through workplace norms that can feel like culture shock after a chain-of-command environment. Launched in May 2024, the nonprofit now serves more than 1,000 users, helping veterans identify target roles and employers, prepare more effectively for interviews, and adapt faster once hired. By turning mentorship into an always-available, highly specific guide, the platform aims to reduce early job churn and help veterans convert experience into confident, mission-ready impact.
# Nonprofits
Kirk Gulezian
Kirk Gulezian · Dec 15th, 2025
This webinar replay builds on the 101 session and goes deeper into more advanced applications for K-12 teachers, staff, and administrators. Watch the replay to explore engagement strategies, productivity workflows, and practical how-to examples for additional features in ChatGPT.
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Sam Canning-Kaplan
Sam Canning-Kaplan · Dec 15th, 2025
Watch the replay for part 1 of our two-part K-12 series, featuring a hands-on walkthrough of ChatGPT and demonstrations of core features and education-specific use cases. Note: This webinar replay is designed to be interactive. To access the slide deck used in the session, including prompts you can copy and follow along with in product, please use the link below. We recommend having ChatGPT open and ready while you watch so you can try things in real time and keep the experience hands-on. bit.ly/OAI-TEACHERS
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Olivia Pavco-Giaccia
Olivia Pavco-Giaccia · Dec 9th, 2025
# K-12 Education
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